Select Publications:
Hussen AS, Kravitz HL, Freudenthal BD, Whitaker AM. Oxidative DNA damage on the VEGF G-quadruplex forming promoter is repaired via long-patch BER.Environ Mol Mutagen. 2023 Aug 22;. PMID: 37606505.
Freund N, Taylor AI, Arangundy-Franklin S, Subramanian N, Peak-Chew SY, Whitaker AM, Freudenthal BD, Abramov M, Herdewijn P, Holliger P. A two-residue nascent-strand steric gate controls synthesis of 2'-O-methyl- and 2'-O-(2-methoxyethyl)-RNA. Nat Chem. 2023 Jan;15(1):91-100. PMID: 36229679
Whitaker AM, Stark WJ, Freudenthal BD. Processing oxidatively damaged bases at DNA strand breaks by APE1. Nucleic Acids Res. 2022 Sep 9;50(16):9521-9533. PMID: 36018803
Max S. Fairlamb, Amy M. Whitaker, Fletcher E. Bain, Maria Spies, Bret D. Freudenthal. 2021. Construction of a Three-Color Prism-Based TIRF Microscope to study the Interactions and Dynamics of Macromolecules. Biology (Basel). PMID: 34201434.
Amy M. Whitaker, Bret D. Freudenthal. 2020. History of DNA polymerase β X-ray crystallography. DNA Repair (Amst). PMID: 33087265.
Amy M. Whitaker, Wesley J. Stark, Tony S. Flynn, Bret D. Freudenthal. 2020. Molecular and structural characterization of disease-associated APE1 polymorphisms. DNA Repair (Amst). Jul-Aug:91-92. PMID: 32454397.
Daniel R. McNeill, Amy M. Whitaker, Wesley J. Stark, Jennifer L. Illuzzi, Peter J. McKinnon, Bret D. Freudenthal, David M. Wilson III. 2020. Functions of APE1 that are critical to cell viability and genotoxin resistance. Mutagenesis. 35:27-38. PMID: 31816044. *This paper was awarded paper of the year by Mutagenesis
Amy M. Whitaker, Rockann E. Mosser, Mandar, T. Naik, and Gregory D. Reinhart. 2019. Propagation of the Allosteric Signal in Bacillus stearothermophilus Phosphofructokinase Examined by Methyl-TROSY NMR. Biochemistry. PMID: 31478644.
Amy M. Whitaker, Bret D. Freudenthal. 2018. APE1: A skilled nucleic acid surgeon. DNA Repair (Amst). 71:93-100. PMID: 30170830.
Max S. Fairlamb*, Amy M. Whitaker*, Bret D. Freudenthal. 2018. Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol. 74(Pt 8):760-768. PMID: 30082511. *Co-first authors
Amy M. Whitaker, Tony S. Flynn, Bret D. Freudenthal. 2018. Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nature Communications. 9:399. PMID: 9374164.
Amy M. Whitaker*, Mallory S. Smith*, Matthew A. Schaich, Bret D. Freudenthal. 2017. Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res. PMID: 28449123. *Co-first Authors
Amy M. Whitaker*, Matthew A. Schaich*, Mallory S. Smith, Tony S. Flynn, Bret D. Freudenthal. 2017. Base excision repair of oxidative DNA damage: from mechanism to disease. Front Biosci (Landmark Ed). 22:1493-1522. PMID: 28199214. *Co-first authors
Amy M. Whitaker, Gregory D. Reinhart. 2016. The effect of introducing small cavities on the allosteric inhibition of phosphofructokinase from Bacillus stearothermophilus. Arch Biochem Biophys. 607:1-6. PMID: 27477958.